Phenergan (Promethazine)

Phenergan Review

Phenergan, either orally or by suppository, is useful for: Perennial and seasonal allergic rhinitis. Vasomotor rhinitis. Allergic conjunctivitis due to inhalant allergens and foods. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Amelioration of allergic reactions to blood or plasma. Dermographism. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Preoperative, postoperative, or obstetric sedation. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.

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Phenergan Drug Class and Mechanism

Promethazine is a phenothiazine derivative that competitively blocks histamine H1 receptors without blocking the secretion of histamine. It has sedative, anti-motion-sickness, anti-emetic, and anti-cholinergic effects However, unlike other phenothiazines, it has no dopaminergic action due to a structural difference with other phenothiazines.

Phenergan Uses

The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. The administration of promethazine HCl in 25-mg doses will control minor transfusion reactions of an allergic nature.

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Phenergan Side Effects

Typical side effects are:

Blurred vision
Confusion in the elderly
Drowsiness, dizziness, fatigue, more rarely vertigo
Dry mouth
Seizures (extremely rare)
Neuroleptic malignant syndrome (extremely rare)
Respiratory depression in patients under age of 2 and in those with severely compromised pulmonal function
Constipation
Euphoria (very rare with high IV doses and/or coadministration with opioids/CNS depressants)
Restless legs

Phenergan Pregnancy

Phenergan Overdose

Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). Stimulation may be evident, especially in children and geriatric patients. Convulsions may rarely occur. A paradoxical-type reaction has been reported in children receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares.

Phenergan More Information

Phenergan Tablets and Suppositories may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment